Change in Serum Chloride and Its Relation to Acute Kidney Injury in Septic Shock Patients

Abstract

Septic shock is a dysregulated host response to infection resulting in potentially life-threatening organ dysfunction. Acute kidney injury (AKI) id one of the most common and serious complications associated with septic shock patients especially in intensive care units. Hyperchloremia is common in critically ill septic patients. The impact of hyperchloremia on the incidence of acute kidney injury (AKI) is not well studied. For this reason, this study was conducted to evaluate the predictive value of change in serum chloride and its relation to acute kidney injury in septic shock patients. The study was included 65 septic patients who admitted to intensive care units of Ain Shams University Hospitals, Cairo, Egypt. All the included cases were subjected to full history taking and full general and local examination. Full laboratory investigations were taken from all the cases. The following were done; GCS, SOFA and APACHE II score. The initial serum chloride level and the highest level of chloride during stay was recorded with calculation the difference as the change of serum chloride level.