Evaluation of Gingival Crevicular Fluid Interleukin-10 in Diabetic Patients Suffering from Periodontitis

Abstract

Periodontitis is a chronic inflammatory , infectious disease affecting the periodontium that results from bacterial infection to the gingival crevice or its products in dental plaque that cross the sulcular epithelium into the connective tissue. The disease results from the interaction between the host response and the bacteria that colonize the gingival crevice or its products, leading to the release of various cytokines and other inflammatory mediators with strong biological effects. Cytokines seem to play an important role in the pathogenesis of periodontitis, many cytokines were identified in the gingival tissues and gingival crevicular fluid. The importance of the GCF raises from the analysis of it's components and the trials of using them as predictors of periodontitis. IL-10 is an anti-inflammatory immunosuppressive cytokine that is produced by numerous cell types including activated T-cells , B-cells, mast cells, natural killer cells and macrophages. It has potent immunomodulatory activities through which it occupies the central role in the development of immune response and inflammatory reaction, also plays an important role in suppressing immune and inflammatory responses by blocking cytokine production and antigen presenting cell function of macrophages. Also , it plays an important regulatory role in limiting the duration and extent of acute inflammatory response. A variety of cells are susceptible to regulation by IL-10, such as T-cells , B-cells, mast cells, natural killer cells and macrophages and PMN.