The Effect of Cardiac Rehabilitation on Quality of Life and 6-minute Walk Test in Breast Cancer Patients after treatment with Anthracyclines

Abstract

of expected of 6MWT (p=0.01) QOL score (p=0.005) with significant improvement in Physical(p=0.019), Functional (<0.0001) and Breast cancer (p=0.001) subscales of the questionnaire in Study group compared to Control group, along with significant decrease in Borg Fatigue post 6 MWT (p=0.003), Borg Dyspnea post 6 MWT (p=0.001). Among the Study Group, There was significant increase in METS (p<0.0001), ET (p<0.0001), Maximal HR (p<0.0001), HRR (p<0.0001) along with significant decrease in Basal HR (p<0.0001) Breast cancer is the most common cancer among women and one of the most important causes of death among them. Adjuvant chemotherapy improves breast cancer survival but can also lead to fatigue, muscle wasting, and reduced physical fitness. This, in turn, can have a negative impact on activities of daily living, social interaction, and health-related quality of life (HRQOL).Exercise programs are increasingly being recognized as an effective strategy to counteract adverse effects of cancer therapy. This was a prospective interventional study performed in Ain Shams University Hospitals in the period from 2/2020 to 8/2020. The study included 60 Female patients diagnosed with early breast cancer (Stage I-III) scheduled for 4 cycles of Neoadjuvent Chemotherapy iuncluding Anthracyclines (either doxorubicin or epirubicin). Patients were randomized by a simple computer generated method into two groups: A study group (n=30) and a control group (n=30) Sixty female breast cancer survivors were enrolled. There were no significant differences between the two groups regarding age, baseline BMI, medical history, chemotherapy protocol, and. When comparing two groups, the study group showed significant increase in 6 MWD (p=0.037), percentage