The Therapeutic Effect of Bacteriophage on Multidrug Resistant Bacteria Causing Diabetic Foot Infection

Abstract

Diabetes mellitus (DM) is a chronic disease that characterized by high glucose concentrations as a result of the inability of the body to adequately produce or use insulin effectively. The World Health Organization predicts that diabetes will be the seventh leading cause of death worldwide in 2030. Moreover, it was expected that the range of diabetics increased from 382 million to 592 million from 2013-2035 according to Centers for Disease Control and Prevention. Egypt is among 10 top countries with the highest prevalence of diabetes and ranked ninth in the world, where there are 7 million and a half million Egyptians are living with diabetes and up to 15–25% of those with diabetes will develop a foot ulcer during their lifetime. Diabetic foot ulcer (DFU) represented the most feared diabetic complication that caused the hospitalization of the diabetic patient. DFU usually characterized with delayed healing as, the diabetic neuropathy, angiopathy and become infected (40%–80%) that leads to the development of gangrene and which even necessi¬tates limb amputation. In recent years,