Effects of pentoxifylline, 7-nitroindazole, and imipramine on tumor necrosis factor-α and indoleamine 2,3-dioxygenase enzyme activity in the hippocampus and frontal cortex of chronic mild-stress-exposed rats

Mohamed, B. ; Aboul-Fotouh, S. ; Ibrahim, E.A. ; Shehata, H. ; Mansour, A.A. ; Az Yassin, N. ; El-Eraky, W. ; Abdel-Twab, A.M. 


Abstract


This study aimed to investigate the role of tumor necrosis factor (TNF)-α and the neuronal nitric oxide synthase enzyme in dysregulation of indoleamine 2,3-dioxygenase (IDO) enzyme, and hence serotonin availability in chronic mild stress (CMS), an animal model of depression.


Other data

Issue Date 2013
Journal Neuropsychiatric Disease and Treatment 
URI http://research.asu.edu.eg/123456789/209
DOI 697-708
http://www.scopus.com/inward/record.url?eid=2-s2.0-84878181000&partnerID=MN8TOARS
9
10.2147/NDT.S41020


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