“Role of E-cadherin, DNA Zinc Finger Protein and Sex Determining Region Y-Box in Diagnosis of Breast Cancer”

Abstract

Breast cancer cells invade and generate metastasis through either lymphatic or blood vessels systems. Interactions between luminal epithelial cells and their surrounding environment are present during the normal development and function of the mammary gland. Alterations in these interactions can induce abnormal intracellular signaling pathways that might affect development and progression of breast tumors. Transcription factors are gaining more attention in the field, since they can be highly effective in treating particular malignancies related to hormone receptors. Also they have controversial and contradictory roles in the field of oncology, during cell proliferation, migration, invasion, tumor metastasis and suppression. Zinc finger proteins C2H2 family like ZEB-1 protein was found to impact the adhesions between cells thus affecting their morphology which contributes to cancer spread. B-cell Lymphoma 11A gene is expressed to a zinc finger protein C2H2 that has a role in lymphoid development and is closely related to B-cell proliferation and differentiation and its aberrant expression is associated with T-cell malignancies. Thus, the current study was designed to investigate the levels