Significance of Aberrant CD 82 Expression in Pediatric Acute Lymphoblastic Leukemia
Mohamed Tarek Aly Ahmed Hassan;
Abstract
Acute lymphoblasticleukemia (ALL) isanaggressiveneoplasm oflymphoid progenitorcells. Itisthemostcommontypeofchildhoodmalignancy.
Specificmarkers havebeenidentified ashavingsignificantdiagnostic and prognostic value and arecurrently used to tailorthe therapeutic strategies.
ThetetraspaninCD82,anadhesionmolecule,performsan importantrole in the interaction between leukemia stemcells (LSCs)and theirniche. CD82 was identifiedasa potentialregulatorofHSPCadhesion and migration.
The presentstudy wasconducted onthirty-five children with newly diagnosed and relapsedALLpatientsandfifteenageandsexmatchhealthycontrol groupfreeofanycancer typeto assessCD8 2expressionin patientswithpediatric ALL.
Allpatientsweresubjectedtofullhistory,clinical examination,laboratory investigationsincluding;CBC,examinationofLeishman-stainedsmears,IPTon
Specificmarkers havebeenidentified ashavingsignificantdiagnostic and prognostic value and arecurrently used to tailorthe therapeutic strategies.
ThetetraspaninCD82,anadhesionmolecule,performsan importantrole in the interaction between leukemia stemcells (LSCs)and theirniche. CD82 was identifiedasa potentialregulatorofHSPCadhesion and migration.
The presentstudy wasconducted onthirty-five children with newly diagnosed and relapsedALLpatientsandfifteenageandsexmatchhealthycontrol groupfreeofanycancer typeto assessCD8 2expressionin patientswithpediatric ALL.
Allpatientsweresubjectedtofullhistory,clinical examination,laboratory investigationsincluding;CBC,examinationofLeishman-stainedsmears,IPTon
Other data
| Title | Significance of Aberrant CD 82 Expression in Pediatric Acute Lymphoblastic Leukemia | Other Titles | أهمية الظهور الضال لــCD82فى سرطان الدم الليمفاوى الحاد في الاطفال | Authors | Mohamed Tarek Aly Ahmed Hassan | Issue Date | 2021 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| BB11031.pdf | 916.52 kB | Adobe PDF | View/Open |
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