Positive Epstein-Barr Virus Detection in Corona Virus Disease 2019 (COVID-19) Patients

Abstract

his observational study held at Ain Shams University Hospitals on fifty Covid-19 positive patients during the period between April 2021 to October 2021. The aim of the current study was to detect frequency of EBV co-infection according to the serological results of EBV viral capsid antigen (VCA) Ig-M antibody among Covid-19 positive patients. patients were included in this study had Confirmed covid-19 infection on basis of clinical history, radiological findings, PCR positive and their age above 18. The study design was approved by the research ethics committee of our institution and a written informed consent was obtained from each patient after all procedures were explained to all participants. All patients included underwent the following: full medical history, clinical examination, Covid-19 PCR and After confirmation COVID 19 positive by 10 days, blood sample (0.5 cm) for EBV viral capsid antigen (VCA) IgM antibody was taken by trained qualified nurse. Antibodies against EBV VCA (IgM) detected by Chemiluminesent Immunoassay Assay (CLIA), Nasopharyngeal swabs were collected from all patients to test for SARS-CoV-2 by real- time RT-PCR. The following points are recorded to all participants gender, age, occupation, fever, comorbidities, EBV viral capsid antigen (VCA) Ig-M antibody. Analytic statistics used in this study are