STUDY OF THE ROLE OF SOLUBLE TRANSFERRIN RECEPTOR/ FERRITIN INDEX IN THE ASSESSMENT OF ANEMIA IN INFLAMMATORY BOWEL DISEASE PATIENTS

Abstract

nflammatory bowel disease either Crohn's or ulcerative colitis are the main cause of IBD. Their etiology and pathogenesis remains unclear but it seems to be multifactorial. The main factors are genetic factors, environmental factors, and immunological factors. Crohn's disease can affect any segment of digestive tract with skip areas.The endoscopic featuresof Crohn's disease are; in the early stage the mucosa is reddish purple showing apthiod ulcers, in later stages ulcerations are linear or serpiginous and the classic cobblestone appearance may arise, sinus tract, stricture, fistulas and fat wrapping.The microscopic features are submucosal lymphedema, lymphoid hyperplasia in lamina propria and submucosa, transmural ivolvement. The most importat microscopic change seen in nearly 60% of patients is the presence of granulomas "non caseating one". The ulcerative colitis disease affects only the colon with continous and symmetrical involvement.The endscopic features include; the mucosa appears hyperemic, edematous and granular in mild disease when the disease progresses the mucosa become heamorragic with visible punctuate ulcers and the patients may develop acute megacolon.The microscopic features include; edema of the lamina propria, congestion of the capillaries and this is followed by acute inflammatory cell