Synthesis, Characterization and Microbiological Studies of Metal Ion Complexes and Nano Coordinated Complexes of Acyclovir Ligand and Schiff Base Ligands Derived from Valacyclovir

Abstract

The present thesis includes five main chapters, and the contents are subdivided into introduction, experimental, results and discussion, theoretical study and biological activity, as well as list of used references, English and Arabic summary. The main chapters can be summarized as: Chapter I: This chapter included an introduction for the literature survey of the previous studies carried out on acyclovir, valacyclovir and Schiff base compounds, their metal complexes, and nano complexes. Different methods for synthesis and different tools for characterization as well as their coordination ability and biological efficiency. Chapter II: This chapter included a detailed account about the experimental procedures used in the present work. The used materials and solvents, the methods of preparation of Schiff base ligands, and their nano metal complexes with metal ions [Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)] in different media (EtOH, CTAB/EtOH, SO/EtOH and MP/EtOH), preparation of used solutions, the physical measurements and apparatus, the working procedures for biological activity, electrical conductivity, as well as molecular modeling and molecular docking. Chapter III: This chapter included the results together with their discussion; it is subdivided into two parts: 1- The first part comprised the results of studying the organic ligands together with their discussion, it included