Relation between postmenopausal osteoporosis and IL-17 serum level

Abstract

steoporosis is a bone condition that makes bones thinner and more fragile because of reduced bone density, and it puts people at risk of fractures, especially of the hip, spinal vertebrae and wrist. The most common form of osteoporosis is postmenopausal osteoporosis; its main reason is estrogen deficiency. In the last years, new evidence of the relationship between immune system and bone have been accounted in humans affected by bone disease, such as osteoporosis and bone metastasis. IL-17 serum level is a pro-inflammatory cytokine secreted by activated T-cells. It’s ligands and receptors may play an important role in the homeostasis of tissues in health and disease beyond the immune system. Now IL-17 serum level considers as a new inducer of bone loss in postmenopausal osteoporosis, and it represents across link between estrogen deprivation and increased immune reactivity. Osteoporosis may be primary or secondary to an