STUDY OF NEUTROPHIL OXIDATIVE FUNCTION IN APPARENTLY HEALTHY OBESE SUBJECTS IN DIFFERENT AGE GROUP

Abstract

he obesity now considered as a major health burden; worldwide obesity has nearly tripled since 1975, in 2016, more than 1.9 billion adults, were overweight, of these over 650 million were obese. 39% of adults above the age of 18 years were overweight in 2016, and 13% were obese. These numbers are the latest data published by the world health organization. Obesity can alter the whole body systems, including the endocrinal and the immune systems, worsening the body response to the harmful factors and events. Obesity is accompanied with a state of chronic inflammation, affecting the innate and the adaptive immune systems, altering the cells responses and reactions. The effect of obesity on immune cells varies from altered number of many cells, the responses, and dysregulation of some functions of these cells. Neutrophils is the largest cell population in WBCs, the first immune cell to face the bacteria and other infectious agents, the neutrophil cells have several different functions to fulfil its role in defense immune mechanism. One of these functions is the oxidative response of the cells, the oxidative function is responsible of killing the engulfed pathogen within the cell.