COMPARATIVE CYTOLOGICAL, CYTOGENETICAL AND MOLECULAR STUDIES ON THE EFFECT OF TAMIFLU AND ADAMINE ON MALE ALBINO MICE

Abstract

Influenza spreads all over the world, especially in the winter, so Tamiflu and Adamine were chosen as antiviral drugs that are commonly used for treatment of different strains of influenza that infect human. Hence, the present study was constructed for the evaluation and assessment of the expected toxicity effects of Tamiflu and Adamine on bone marrow chromosomes, DNA in addition to their effect on histology and ultrastructure of liver of adult male albino mice Mus musculus and to compare the pathogenic impacts of both drugs. In order to achieve these intended goals, the experimental design was carried out in the following manner: 150 adult male albino mice (12-13 weeks) were used in the present study. They were allocated into 10 equal groups. The first group served as control group and each animal was treated orally with the solvent of the drug (0.9 % NaCl) and the second, third and fourth groups were Tamiflu treated groups. Each animal from these groups was treated orally with (16 mg/kg b.wt.) of Tamiflu daily for five, ten and fifteen days, respectively.