THE POSSIBLE PROTECTIVE ROLE OF PLANT POLYPHENOLS AGAINST THE GENOTOXICITY OF ACROLEIN ON BONE MARROW CHROMOSOMES AND DNA IN MALE ALBINO MICE

Abstract

Natural polyphenolic substances exist in several foods and drinks of plant origin such as fruits, vegetables, tea and coffee, protect against the oxidative stress of reactive oxygen species and promote human health. Acrolein is a reactive α, ß-unsaturated aldehyde, causes cytotoxicity, genotoxicity and mutagenic effects. The present work is mainly concerned with the study of the protective effect of two plant polyphenols, quercetin and/or resveratrol, against the cytotoxicity, clastogenicity and genotoxicity of acrolein on bone marrow chromosomes and DNA content of male albino mice (Mus musculus). One hundred mice (CD-1) were acclimated for one week and randomly assigned to one of ten groups, comprising of ten animals each as follows: Group 1: mice served as a control group and received distilled water (the acrolein’s solvent) orally at same volume as acrolein treatment. Group 2: mice served as quercetin-vehicle control group and received corn oil (the quercetin’s vehicle) orally at same volume as quercetin for eight