″Effect of Celastrol in acute kidney injury in mice″

Abstract

Kidney has many important functions and its main function is to filter and excrete waste products from the blood .Acute kidney injury is a critical health issue which affect the kidney functions and can cause rapid deterioration of kidney and retention of nitrogenous waste products over a period of hours or days and also associated with structural damage. AKI must be handled in a proper treatment way to avoid permanent damage of renal tissues and progression to mortality. There are many reasons can cause AKI such as hypovolemia, atherosclerosis, severe bleeding and sepsis. Septic-AKI is more severe than non-septic AKI with different underlying mechanisms. With many causes for septic AKI, infection with Gram negative bacteria is still the leading main cause of this serious case. Lipopolysaccharides , is mainly the virulent part of the Gram negative- bacteria outer membrane and it was found that LPS is main cause of sepsis- induced acute renal injury. So, the need to use effective treatment for AKI is increasing. Toll-like receptors (TLRs) are group of receptors with many roles in innate immune system, TLR4 is one of this group and LPS is its main ligand. When LPS binds and activates TLR4 and so inflammatory cascade through production of cytokines such as TNFα, IL-1β and IL-6 leading to inflammation and damage of surrounding tissue.

Celastrol a natural compound extracted from the root extracts