SYNTHESIS OF SOME NOVEL PURINES AND THEIR BIOISOSTERIC DERIVATIVES AS POTENTIAL BIOLOGICALLY ACTIVE AGENTS

Abstract

It has been well documented that purines, fused purines as well as purines linked to other heterocyclic rings possess a broad specturm of biological activities, especially anticancer, antiviral, antibacterial and antifungal activities. These facts initiated the design of novel purine derivatives as potential chemotherapeutic a~ents. Also, in an effort to widen the scope of the present investigation, certain benzoxazole derivatives were synthesized as bioisosteric relatives to purine in a trial to evaluate their anticancer, anti-Human Immunodeficiency Virus (HIV), antibacterial and antifungal activities. The thesis is divided into the following chapters: Chapter I Introduction: This chapter is subdivided into two parts: Part I: includes a brif survey on some pharmacological aspects of purine derivatives such 'as antineoplastic, antiviral, antimicrobial, bronchodilator and antihistaminic, antiinflammatory, CNS and adenosine receptors antagoni; st actr~v,tes, lconcenrati.ng on theie recent researchches. Part II: deals with a survey of biologically active benzoxazoles in the field of antineoplastic, antiviral, antimicrobial, anthelmintic, analgesic and antiinflammatoJ agents focusing on the recent researches .