The Effect of Some Beverage Rich in Chlorogenic acid on Rats Suffering from Chronic Liver Damage Induced by Carbon Tetrachloride

Abstract

Chronic liver disease refers to on-going inflammation in the liver for at least 6 months with the potential to progress to cirrhosis and end-stage liver disease. It involves a spectrum of conditions that includes chronic hepatitis and cirrhosis. Herbs, which are well known for their long history of proven therapy of various diseases with low cost and few side effects, have potentials in the treatment of Chronic liver disease. Therefore, the aim of the study was to investigate the beneficial effects of some beverage rich in chlorogenic acid like green coffee, roasted coffee, green tea and black tea on serum glucose, liver function, kidney function, histopathology and serum lipoproteins of rats suffering from chronic liver damage induced with carbon tetrachloride. Experiment design Forty-two male albino rats weighing 150±10 g used in the present investigation. The animals supplied from the animal house colony of the National Research Center, Dokki, Cairo, Egypt. Rats were housed 7 per cage with wood shave bedding and were fed standard basal diet as reported and water ad libitum. The experimental protocols were approved and carried out according to the local experimental ethics committee. All animals were conditioned at room temperature at a natural photoperiod for 1 week before experiment execution, then divided into two main groups as follows: The first main group: (7 rats) fed on basal diet, as a negativ