Gene Expression Levels of Low Molecular Weight Protein Tyrosine Phosphatase and Mucin 4 in Egyptian Patients with Acute Myeloid Leukemia

Abstract

Acute myeloid leukemia accounts for 1.45% of all cancers and for 32% of newly diagnosed acute leukemia in Egypt. Treatment of AML strategies needs to be developed by identifying new markers and targets for treatment because about 50% of patients die due to aggressive disease and the percentage of old patients that survive more than 5 years with this disease is less than 10%. It is required to identify good molecular markers that precisely characterize this disease MUC4 gene expression is associated with poor outcomes in many solid tumors including pancreatic, colon and stomach cancers and is regarded as a prognostic factor in these tumors and its high expression of MUC4 is regarded as one from the important prognostic factors of chemotherapeutic failure in high risk pediatric B-ALL. LMWPTP (ACP1) gene overexpression was regarded as a potential marker for primary stages of tumorigenesis. It is overexpressed in many solid tumors as colon, prostate, colorectal cancers and neuroblastoma and this overexpression is accompanied by worse treatment outcome and low surviva