Identifying Immune Markers to Differentiate between Viral and Non-Viral Hepatitis

Abstract

HCV represents a global health problem affecting a high range of population worldwide. It is the main cause of liver inflammation. Meanwhile, hepatitis may be caused by an autoimmune disorder, in which the body’s immune system attacks the normal liver cells because it became unable to differentiate between harmful invaders and healthy liver tissues. Thus, differentiation between different causes of liver inflammation due to various etiologies still represents big challenge. Therefore, this study sought to develop new immunodiagnostic markers able to differentiate between different types of inflammation. The study was performed on eighty-one blood samples collected from the medical unit at the national research center starting from October 2016 till May 2019. The samples were divided into seven groups as follow:

Group (1); normal: nine healthy control volunteers with no history of HCV-infection, liver disturbance diseases or autoimmune diseases. Group (2); HCV: eleven- HCV infected patients with no history of autoimmune diseases. Group (3); HCV+auto: eleven-HCV infected patients who are