Design and Synthesis of Some New Thiazole, Pyridine and Pyrimidine Derivatives for Biological Evaluation
Manar Elsaied AbdElsatar Elasasy;
Abstract
Design and Synthesis of Some New Thiazole, Pyridine and Pyrimidine Derivatives for Biological Evaluation
The purpose of this work is to synthesize novel biologically active compounds as drugs analogues through the following two parts:
Part 1: Synthesis, characterization and investigation of antiproliferative activity of novel thiazole, pyridine and pyrimidine derivatives using Fluoroacetophenone
In this part of study, 4- fluoroacetophenonethiosemicabazones 3a-c were synthesized by reacting 4-flouroacetophenone 1 with the thiosemicarbazides 2a-c in the presence of few drops of conc. HCl , in refluxing ethanol (Scheme 1).
The purpose of this work is to synthesize novel biologically active compounds as drugs analogues through the following two parts:
Part 1: Synthesis, characterization and investigation of antiproliferative activity of novel thiazole, pyridine and pyrimidine derivatives using Fluoroacetophenone
In this part of study, 4- fluoroacetophenonethiosemicabazones 3a-c were synthesized by reacting 4-flouroacetophenone 1 with the thiosemicarbazides 2a-c in the presence of few drops of conc. HCl , in refluxing ethanol (Scheme 1).
Other data
| Title | Design and Synthesis of Some New Thiazole, Pyridine and Pyrimidine Derivatives for Biological Evaluation | Other Titles | تصميم وتشييد بعض مشتقات الثيازول والبيريدين والبيرميدين الجديده للتقييم البيولوجي | Authors | Manar Elsaied AbdElsatar Elasasy | Issue Date | 2021 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| BB11725.pdf | 2.43 MB | Adobe PDF | View/Open |
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