Platelet Glycoprotein VI Genetic Polymorphism T13254C in Neonatal Sepsis

Abstract

eonatal sepsis remains a leading cause of morbidity and mortality worldwide. It represents a global burden and an area of dynamic research. It is a systemic infection occurring in infants at ≤28 days of life. Emerging evidence indicates that platelets, which have a well- established role in the pathophysiology of thrombosis, have a complex role in modulating inflammation. Indeed, studies have associated platelets with both pro- and anti-inflammatory effect. It has been proved that the expression of the GPVI protein (activator receptor for collagen) is genetically determined and that some polymorphisms in these genes affect their expression, thus influencing the coagulation processes. We focus on GPVI as it contains common genotypic polymorphic haplotypes associated with altered platelet GPVI- dependent signaling. In this study we aimed to study the presence of platelet glycoprotein VI genetic polymorphism in early onset full term neonatal sepsis and correlate with other standard risk factors; moreover, its impact on sepsis progression and outcome; additionally, evaluate its relevance with dif