FAS EXPRESSION IN SOME COMMON CUTANEOUS NEOPLASMS

Abstract

The Fas was the most important gene identified as an inducer of apoptosis by ligation with its Fas ligand.

The Fas expression in some neoplastic derrnatoses may suggest a role in their pathogenesis. Thus, this study aimed at investigating the expression of Fas and its possible role in the pathogenesis of some malignant cutaneous neoplasms (SCCs, BCC, MF, MMs).

Sixty patients (15 with secs. 15 with BCCs, 15 with MF and

15 with MMs) were recruited from to Out Patient Clinic of Dermatology and Vernereology Department, Tanta University Hospital. Fifteen normal persons, of the same age and sex matching with the patients, served as control.

For all, the following were done:

1- Complete history taking.

2- General & dermatological examination.

3- Laboratory investigations:

* Complete blood picture.

* Urine and stool analysis

* Blood glucose level.

• Renal & hepatic function tests.

4- Skin biopsies from lesional areas were obtained for:

* Histopathological confirmation of clinical diagnosis.