SYNTHESIS OF CERTAIN TETRAHYDRONAPHTHYL THIAZOLES OF POSSIBLE BIOLOGICAL ACTIVITY

Abstract

In the present work, a variety of tetrahydronaphthyl thiazole derivatives was prepared for the purpose of evaluation as antiparasitic or as antimicrobial agents. These compounds include 1-alkyl(or aryl)-3-[4-[6• (1,2,3,4-tetrahydronaphthyl) thiazol-2-yl] ureas and thioureas. In addition, several reactions were carried out on the heterocyclic compounds to obtain a series of possible biologically active N-3-[6-(1,2,3,4-tetrahydronaphthyl)]-2- arylthiazolidin-4-ones and their Mannich bases. Synthesis were achieved through different routes of chemical reactions and transformations starting with 6-amino tetralin and 2-amino-4-[6-(1,2,3 ,4-tetrahydronaphthyl)]thi azole. All of the new compounds were confirmed with concordant microanalytical data, IR, 1 HNMR and Mass spectra. Some of the newly synthesized compounds were found to exhibit various inhibitory effects on egg masses production of Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni. Also some other compounds showed antimetabolic effect in experimental animals livers, and antimicrobial effects. Moreover, one of the newly synthesized compounds (Compound IVc) showed moderate activity against human immuno deficiency virus type-1 (HIV-1) (Anti• Aids) and anticancer against malignant tumors (anticancer)*