Measure the level of Ascetic Fluid Mannose Binding Lectin in Patients with Spontaneous Bacterial Peritonitis And possibility for using as an indicator for inflammation

Abstract

Spontaneous bacterial peritonitis is a very common bacterial infection in patients with cirrhosis and ascites, when first described its mortality exceeded 90% but it has been reduced to approximately 20% with early diagnosis and treatment. Mannose-binding lectin (MBL) is an important protein of humoral innate immune system with multiple carbohydrate recognition domain , it is able to bind to sugar group displayed on the surface of wide range of micro organism and therepy provide first line defense, it is also occur activate complement MBL produced in liver in response to infection and is a part of many other factor termed acute phase protein. MBL deficiency has been reported as risk factor for infection. Finally, the MBL deficiency predisposes patient with liver cirrhosis to develop SBP. In the present study, we aimed to study the