SYNTHESIS AND REACTIONS OF N-GLYCOSIDES OF SOME 1,2,4-TRIAZINES OF EXPECTED BIOLOGICAL ACTIVITY

Abstract

This work has been carried out to investigate selective synthetic routes towards the J new 2-3-D-galactopyranosyl and 2-a-L-arabinopyranosyl derivatives of some 6•

substituted-3-thioxo-2,3-dihydro-1,2,4-triazin-5(4H)-ones and some 3-phenyl-5• benzyl( or substitutedbenzyl)-1,2,4-triazin-6(1H)-ones / or 6(1H)thiones. Also, some chemical transformations were applied to these new 1,2,4-triazine glycosides leading to their new functionalities. These reactions included: deamination, condensation, thiation, alkylation, thermolysis, and deacetylation. The structure of all new compounds was established chemically and spectroscopically. In the present work ' some of the prepared glycosyl derivatives were testified for their human anticancer activity using an in vitro model through a 3-cell line, one dose anticancer assay consisting of MCF7 (Breast), NCI-H460 (Lung), and SF-268 (CNS). Among the testified compounds, there was one compound that exhibited activity against SF-268 (CNS) in this 3-cell line, one dose primary human anticancer assay.