Fatigue in Parkinson’s Disease: is it Primary or Secondary?

Abstract

Background: Fatigue is generally defined as a sense of exhaustion for a defined period that is unexplained by drug effects, medical, or psychiatric disorders. In Parkinson's disease (PD), fatigue is considered one of the most common and disabling non motor symptoms, which may manifest even during premotor stages of disease, and once present may often persist or even worsen over time Aim of the study: is to study fatigue whether it's primary or secondary in idiopathic Parkinson’s disease (PD) patients. Methods: A case control study was conducted on 50 patients with Parkinson's disease attending movement disorders outpatient clinic at Ain Shams University Hospitals and Ain Shams University Specialized Hospital and 50 control subjects of relatives or accompanying person of the patients. UPDRS scale, PD NMS questionnaire, Parkinson's disease fatigue scale, Pittsburg sleep quality index, RBDS questionnaire, Restless legs syndrome scale, Beck depression scale and Parkinson's anxiety