"The Role of Chronic Administration of Ampicillin/Sulbactum on the Developmental Enamel Defects in Albino Rats" (Histological Study through Scanning Electron Microscope and Quantitative C.T. )

Abstract

Tooth development is genetically controlled but susceptible to environmental disturbances. Disturbances during the transitional and maturation stages of amelogenesis result in pathologically soft, hypomineralized enamel. The stage of development of the dentition is dependent on the age and therefore, susceptibility of different teeth or tooth groups to developmental disturbances at different times varies. The crowns of human permanent incisors and first molars mineralize during the first year of life and therefore they are at greatest risk for developmental enamel defects such as fluorosis and molar incisor hypomineralization during that period. In early childhood, a high proportion of children get antibiotics for the treatment of acute otitis media or other common childhood infections. Antibiotic intake could also be necessary during mother pregnancy. Unictam (Ampicillin/Sulbactam) is considered to be a drug of choice to many physicians as it considered safe during childhood and pregnancy. Unictam is one of the Beta lactam broad spectrum