COMPARISON BETWEEN TADALAFIL AND TAMSULOSIN IN RELIVING STENT RELATED SYMPTOMS: A RANDOMISED STUDY

Abstract

The aim of the present study was to evaluate and compare the efficacy and safety of Tadalafil and Tamsulosin in reliving Double-J stent-related symptoms following uncomplicated ureteroscopic lithotripsy (URSL) and percutaneous nephrolithotomy (PCNL).

The present study was a prospective randomized comparative study conducted on 80 patients (56 men and 24 women) with double-J stent inserted following uncomplicated ureteroscopic lithotripsy (URSL) and unilateral percutaneous nephrolithotomy (PCNL) in Ain Shams University Hospital and Sohag Educational hospital over a period of 1 year.

The patient were randomized into 2 equal groups (1:1randomization): Group A: 40 patients were treated by Tadalafil (5 mg) once daily. Group B: 40 patients were treated by Tamsulosin (0.4 mg) once daily. All patients were assessed 1 week postoperatively after Double-J stent insertion before treatment. Then, the patients were started the medical treatment and were assessed 3 weeks with medical treatment.

The study shows that Tadalafil is safe and effective in relieving DJ related symptoms. Tadalafil 5 mg once / day is as effective as Tamsulosin 0.4 mg once / day in relieving urinary symptom and body pain but more effective in relieving sexual symptoms and general health. Therefore Tadalafil 5 mg once / day could be recommended as preferred drug in sexually active patients undergoing DJ stenting. Also, the drugs are safe with mild few side effects.