MEASURMENTS IN NEPHROTIC SYNDROME IN CHILDREN

Abstract

Nephrotic syndrome is one of the commonest chronic renal diseases of childhood, with an incidence of 2-7 per 100,000 children per year. It is a disease of major concern as it causes significant morbidity for * i children, inconvenience and anxiety for families, and considerable consumption of medical resources (Chesney, 1999). Children suffering from nephrotic syndrome are liable to several complications that may occur as a part of the disease itself or as a consequence of therapy (Tsau et al, 1991). Disturbance in the coagulation and fibinolytic systems is one of the most important complications that has been found in many nephrotic 1 patients; it results in »a hypercoagulable state with increased risk of thromboembolic problems (Handin, 1991). 1 A hypercoagulable state and the risk of thromboembolism in both arterial and venous circulation is a relatively frequent and serious feature of nephrotic syndrome in children (Citak et ai, 2000). Approximately 20% Of nephrotic patients are affected with arterial and venous thrombosis (Andre et al, 1994). Several homeostatic aberrations have a key role in the thromboembolic events associated w:th NS as platelets disorders, bearing on the number of« platelets and fftnetion, increased levels of some coagulation factors, and deficient natural inhibitors of ; coagulation as antithrembin III and protein S (Citak et al, 2000).