Effect of Narrow-Band UVB on Serum and Tissue Vitamin D Level in Vitiligo

Abstract

INTRODUCTION V itiligo is an acquired skin disorder caused by the disappearance of melanocytes from the epidermis that gives rise to well-defined white patches. It occurs worldwide in about 0.5% of the population and it occurs as frequently in males as it does in females. The cause is unknown, but might involve genetic factors, autoimmunity, neurologic factors, toxic metabolites, and lack of melanocyte growth factors. Vitiligo is commonly associated with systemic autoimmune conditions. Many autoimmune conditions have been found to be associated with reduced vitamin D levels (Sehgal et al., 1976; Niepomniszcze and Amad, 2001; Montes et al., 2003; Adorini and Penna, 2008).