Role Of Circulating Ectodysplasin A as a Biomarker in Non-alcoholic Fatty Liver Disease

Abstract

The liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disorder worldwide, and is closely associated with insulin resistance and type 2 diabetes. Nonalcoholic fatty liver disease (NAFLD) is defined by the accumulation of fat in the liver, in the absence of excessive alcohol consumption and other causes of hepatic steatosis, and encompasses a spectrum of conditions. There is an incomplete understanding of the factors mediating the close relationship between NAFLD and diabetes, with the likelihood of multiple contributing factors. The secretion of liver-derived proteins, which are known as hepatokines, is altered in NAFLD Ectodysplasin A (EDA) is a new hepatokine and a protein of the tumor necrosis factor family. It was recently identified as a liver-secreted protein that is increased in the liver and plasma of obese mice and causes skeletal muscle insulin resistance. The aim of work of the current study was to study serum le