ANALYSIS OF SOME ANGIOTENSIN CONVERTING ENZYME INHIBITORS USED IN THE TREATMENT OF HYPERTENSION

Abstract

Analysis of some angiotensin converting enzyme inhibitors used in the treatment of hypertension In this thesis, different methods of analysis of some angiotensin converting enzyme inhibitors are proposed. The studied drugs are enalapril maleate, ramipril, lisinopril and fosinopril sodium. The drugs were analysed in both pure and dosage forms. Statistical comparison between these methods with official or reported method is also represented. The thesis is presented through the following parts: 1-Introduction: A- In this part, a resume about angiotensin converying enzyme inhibitors, pharmacological effect, classification of their different groups, structure activity relationship. B- A literature review for the official and reported methods for the determination of drugs in concern is given. 2-Aim_of the present work In this part the aim of this work and the basis on which the proposed methods were chosen, have been clarified.