"Clinical and Biochemical Assessment of Nanohydroxyapatite Combined with Lycopene Gel in Treatment of Grade II Furcation Defects: A Randomized Controlled Clinical Study"

Abstract

Furcation area poses an additional challenge for the clinician to manage. Regeneration is a recommended treatment option for molars with Class II (FI) and this approach should be considered before other treatment modalities. The aim of this study was to evaluate the effect of lycopene gel mixed with nanohydroxyapatite and collagen membrane in treatment of grade II furcation defects clinically and radiographically. Thirty-two systemically healthy patients were selected from the outpatient clinic of Periodontology Department, Faculty of Dentistry, Ain Shams University, and October 6th University. All subjects had localized periodontitis Stage III Grade B and they are divided into 3 groups as follows: Group I: included 8 furcation class II sites managed by surgical debridement with lycopene gel mixed with nanohydroxyapatite bone graft and covered by occlusive collagen resorbable membrane and was considered the (Test group). Group II (Control group): included 8 furcation class II sites managed by surgical debridement with placebo gel mixed with nanohydroxyapatite bone graft and covered by occlusive collagen resorbable membranes and was considered (Positive control Group). Group III (Control group): included 8 furcation class II sites managed by open flap debridement only and was considered (Negative control group). Clinical parameters were recorded at base line and after 6 months