A Study of the Protective Role versus the Curative Role of Pentoxifylline on Experimentally Induced Diabetic Nephropathy in a Rat Model
Hanan Mohammed El Sayed Tarabeh;
Abstract
he present study aimed to evaluate the possible protective and curative effects of pentoxifylline on diabetic nephropathy.
The rats were randomly divided into five groups as follows:
1. Group I (twenty rats): served as control group. It was further subdivided into two equal subgroups:
Group Ia: It received 200ml/kg distilled water using gastric intubation daily.
Group Ib: It was injected intra-peritoneal with a single dose of one ml/kg body weight of sterile citrate buffer 0.1N solution.
2. Group II (PTX treated group) (ten rats): It received a single daily dose of pentoxifylline throughout the duration of experiment (eight weeks) using gastric intubation.
3. Group III (Diabetic nephropathy group) (ten rats): It was injected intra-peritoneal with STZ only.
4. Group IV (DM+PTX as prophylactic treatment) (ten rats): Diabetic rats received a single daily dose of pentoxifylline as a protective treatment starting
The rats were randomly divided into five groups as follows:
1. Group I (twenty rats): served as control group. It was further subdivided into two equal subgroups:
Group Ia: It received 200ml/kg distilled water using gastric intubation daily.
Group Ib: It was injected intra-peritoneal with a single dose of one ml/kg body weight of sterile citrate buffer 0.1N solution.
2. Group II (PTX treated group) (ten rats): It received a single daily dose of pentoxifylline throughout the duration of experiment (eight weeks) using gastric intubation.
3. Group III (Diabetic nephropathy group) (ten rats): It was injected intra-peritoneal with STZ only.
4. Group IV (DM+PTX as prophylactic treatment) (ten rats): Diabetic rats received a single daily dose of pentoxifylline as a protective treatment starting
Other data
| Title | A Study of the Protective Role versus the Curative Role of Pentoxifylline on Experimentally Induced Diabetic Nephropathy in a Rat Model | Other Titles | دراسة الدور الوقائي مقارنة بالدور العلاجي لمادة البنتوكسيفيلين على اعتلال الكلى السكري المستحدث في الفئران | Authors | Hanan Mohammed El Sayed Tarabeh | Issue Date | 2022 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| BB12026.pdf | 745 kB | Adobe PDF | View/Open |
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