Evaluation of the effect of different types of non steroidal antiinflammatory drugs (NSAIDs) on osseointegration of dental implants

Abstract

A dental implant is a device that is capable of replacing the functions of natural tooth or teeth (Alberktsson, 1983). Dental implants have become a successful and commonly used modality in the treatment of both totally and partially edentulous patients requiring prosthetic teeth replacement with significant importance for prosthetic techniques (Dymtryk, 1990). Osseointegrated implants need stable interfacial conditions for bone to develop and, according to Alberktsson (1988), any movement in the early healing stage may shift the stimulus towards more soft tissue cells formation. Non steroidal antiinflammatory drugs (NSAIDs) are among the most frequently prescribed medications and are used primarily to control pain, stiffness, and reduce inflammation. They are a group of chemically dissimilar agents that differ in their antipyretic, analgesic, and antiinflammatory activities. They block prostaglandins synthesis by inhibiting the action of cyclooxygenase on arachidonic acid (Offenbacher et al., 1993; Bahl et al., 1994 and De Broe and Elseviers, 1998). Although aspirin is the most commonly used type of NSAIDs, some of the newer NSAIDs are marginally superior to aspirin in certain patients because they have greater antiinflammatory activity and/or cause less gastric irritation {Hannig et al., 1992).