The Possible Therapeutic Effect of Aloe Vera versus Silver Nanoparticles on Acid Induced Lip Ulcer in Albino Rats )Histological and Immuno-histochemical Study(

Abstract

Ulcers are very common diseases of the oral mucosa with high prevalence all over the world. They are characterized by interruption in the epithelium, connective tissue or both and are painful in general. The focus on oral ulcer research helped to establish a better way for early prevention and effective treatment. Several anti-inflammatory treatments such as topical steroids and antibiotics were used to promote tissue repair and prevent further infection. They are prescribed to relieve the pain or reduce both the duration and frequency of ulcer onset time. However, long term application of topical antibiotics or steroids may cause atrophy, irritation, discoloration, fungal infection and bacterial resistance. Topical application of Aoe Vera (AV) and Silver nanoparticles (AgNPs) showed regenerative, anti-inflammatory and anti-microbial capabilities enabling them for being a good treatments option for ulcer healing.