Study the Role of Glutathione-S-Transferase Gene Polymorphism and its Relation to Aluminium level in Autistic Children (Interventional Study)

Abstract

Autism spectrum disorders (ASDs) are group of neurodevelopmental disorders characterized by persistent deficits in social communication, interactions with repetitive patterns of behaviors and restricted interests or activities. The prevalence of autism was increased in the last few decades; data show that about 1 in 44 of children was identified with ASDs. It is four times common in males than females. The increased prevalence could not be explained by advances in diagnosis but multiple lines of evidence suggested that oxidative stress could represent the basis for the observed association between genetic immune-inflammation and environmental factors underlying autism spechum disorders, and suggested also a role of glutathione S-transferases polymorphism in ASD development. when taking into account the important role of GSTs enzyme in detoxification. Aluminium is the third most common abundant metal on earth, that have changed the world, as it has been used extremely in the past five decades in every products, and we became exposed to many sources like aluminium cookwares, aluminium foil, food additives, medications, tap water and cosmetics; which raise our exposure to this metal, and we are facing the aluminium era with its bad effects on environoment and human health. It has been proposed that aluminium exposure may contribute as an environomental factor that cause ASD and increase its frequency. Multiple studies reported the remarkable higher aluminium concentration in ASD children compared to the neurotypical one.