COMPARATIVE STUDY BETWEEN THE EFFECTS OF SEVOFLURANE AND HALOTHANE ON THE INTERCELLULAR ADHESION MOLECULE-1 (ICAM-1) IN THE PREVIOUSLY ANAESTHETIZED PATIENTS

Abstract

This study was done to compare the effects of sevolurane versus halothane on the level of intercellular adhesion molecule -1 (CAM-1)' of 'patients previously exposed to halothane anesthesia within the previous year. This study included 40 patients , their ages ranged from 18 -- 52 years undergoing different types of surgery either ophthalmic, EN.T , plastic neurosurgical or extraperitoneal abdominal operations. Patients were divided according to the type of inhalation anesthetic used into 2 equal groups : Group(I): 20 patients received sevoflurane and have previously • been exposed to general anesthesia with halothane within the previous year. Group (II): 20 patients received halothane and have previously been exposed to general anesthesia with halothane within the previous year. Premedication was done with fentanyM (l ug/ Kg) given 15 minutes before induction and atropine sulphate (0.01)mg/ Kg immediately before induction of anesthesia. Induction was done with a sleeping does of (4-7 mg/ Kg.) of 2.5% Sodium thiopentone then succinlcholine (Img/Kg) followed by oxygenation for one minute then oral endotracheal intubation was done under direct laryngoscopy.