Protective Effect of Vitamin "E" Against Toxicity and Teratogenicity of Iron
Shereen Abd-EI-Hakeem Abd-EI-Aleem;
Abstract
Iron-dextran complex has been shown to be teratogenic in pregnant experimental animals. The most pronounced teratogenic effect after intraperitoneal administration of iron to experimental animals is exencephal1y (Brigitte, 1982).
Dietary alpha-tocopherol (vitamin E) supplementation has a protective and an antioxidant effect in vivo iron overload in experimental animals. Vitamin E has an important role in the prevention of nephrotoxicity and hepatotoxicity produced by iron (Galleano and Puntarulo, 1997; Lawrence et al., 2002).
Aim of the work:
The aim of the work is to study the effect of iron toxicity on different body organs (liver, kidney and heart) and its teratogenic effect. Also, to determine the protective effect of vitamin E in iron overload disorders
Dietary alpha-tocopherol (vitamin E) supplementation has a protective and an antioxidant effect in vivo iron overload in experimental animals. Vitamin E has an important role in the prevention of nephrotoxicity and hepatotoxicity produced by iron (Galleano and Puntarulo, 1997; Lawrence et al., 2002).
Aim of the work:
The aim of the work is to study the effect of iron toxicity on different body organs (liver, kidney and heart) and its teratogenic effect. Also, to determine the protective effect of vitamin E in iron overload disorders
Other data
| Title | Protective Effect of Vitamin "E" Against Toxicity and Teratogenicity of Iron | Other Titles | التأثير الواقى لفيتامين "هـ" ضد تسمم وتشوه الاجنة بالحديد | Authors | Shereen Abd-EI-Hakeem Abd-EI-Aleem | Issue Date | 2005 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B17181.pdf | 2.53 MB | Adobe PDF | View/Open |
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