Effect of Central Dialysis Fluid Delivery System (CDDS) on IL6 & CRP Levels in Prevalent Haemodialysis Patients

Abstract

n HD patients, inflammatory mediators, such as IL-1, IL-6, and tumor necrosis factor alpha, cause synthesis and release of C-reactive protein (CRP), decreased albumin, prealbumin, and increased homocysteine and endothelin I. However, IL-6 and hsCRP, besides being inflammatory markers, have emerged as independent predictors of mortality in ESRD patient. Currently available dialysis fluid delivery systems include the single-patient dialysis fluid delivery system (SPDDS) and central dialysis fluid delivery systems (CDDS). This study was conducted on 100 end-stage renal disease on hemodialysis patients, they were divided into two study groups each included 50 patients. Group (1) included patients receiving regular dialysis by central dialysis fluid delivery system (CDDS) for at least one year before starting the study, while group (2) receiving regular dialysis by single patient dialysis fluid delivery system (SPDDS). Patients underwent full clinical assessment including thorough history taking, clinical examination, routine investigation, IL-6 and hsCRP testing to all patients. Central dialysis fluid delivery system (CDDS) seems to have a better effect on systemic inflammation (IL-6 and