Evaluation of Cyst Fluid Interleukin-1b (IL1b) Level in the Prediction of the Risk of Carcinoma in Pancreatic Cyst

Abstract

he pancreas is an important digestive organ located in the upper abdomen. The pancreas has exocrine and endocrine functions. Many cysts can originate in the pancreas. Some of them can be precancerous. These cysts can be classified according to morphology, constituent or malignant tendency. The common pancreatic cysts types are pseudocysts, serous cystadenoma, intraductal papillary mucinous neoplasia, and mucinous cystic neoplasm. Current treatment recommendations based upon the recently published International Consensus Guidelines dictate a different treatment algorithm for different pancreatic cystic lesions that is why it is important to differentiate between them. In conclusion, this study demonstrated that preoperative clinical characteristic such as patients’ age, tumor size, cystic fluid IL-1B can predict malignancy in the cyst. imaging scan is not sufficiently accurate to differentiate among the benign and malignant pancreatic cystic lesions. Cystic fluid CEA and IL-1B can differentiate between mucinous and non-mucinous cysts, and between