Intensive conventional chemotherapy ACVBP regimen) compared with CHOP-VP16 for aggressive non-Hodgkin's lymphom'a . .

Abstract

Non- Hodgkin's lymphomas (NHL) are lymphoid neoplasms

that can arise from i:lifferent stages of lymj-hocyte differentiation pathway. So these neoplasms are heterogenous in their morpholo- gi• cal freatures as wet, I as tJ e .r c 1 •nu.cai, ' e , . • .. r. h i b

haviou

( . Patients with poor prognosis aggressive NH.L still have poor

This prospective phase III clinical trial was conducted to I

study the efficacy of ACVBP versus CHOPsVP16 regimens. "J This study was done between September 2003 to December I 2005 at the NCI, Cairo University and medical oncology I department, Zagazig University. Eighty-seven patients with pathologically proven aggressive NHL were included in the study. I

The clinical characteristics of the 87 patients in this study I

were as follows; the age range was 20 -60 years (median age 46), I 62 % of patients were males and 38 % were females. Systemic B I symptoms were encountered in 48 % of patients, while extranodal

involvement was encountered in 33 % of patients. I

According to Ann Arbor staging system, I. I % of patients I

had stage I disease, 2.3 % stage II disease, 51. 7 % stage III disease I and 44.9 % stage IV disease. Pathological classification according