STUDY OF HEAT SHOK PROTEIN 32 (HSP -32) IN POST RENAL TRANSPLANT PATIENTS: CORRELATION TO RENAL HAEMODYNAMICS, GRAFT FUNCTION AND SURVIVAL

Abstract

Renal transplantation is considered the treatment of choice for most end stage renal disease (ESRD) patients; all patients with ESRD are considered candidates for renal transplantation unless they have systemic malignancy, chronic infection, severe cardiovascular diseases or neuropsychiatric disorders. Renal transplantation can be performed before w patients requiring dialysis. It is the decision of the patient whether to choose dialysis or renal transplantation as a form of renal replacement therapy. Carbon monoxide (CO) is a gaseous molecule, endogenously generated by vascular cells as a byproduct of heme catabolism. It is a potent vasodilator and decrease platelet aggregation. Heme oxygenase (HO) catalyzes the degradation of heme to CO, iron and biliverdin. There are till now, three isoforms of HO, has been characterized (HO-1, HO-2, HO-3), of them HO-1 is the inducible and responsible for the major part of the enzyme activity. The aim of the present work was to study the plasm~ level of HO-1 and blood concentration of carboxyhemoglobin (COHb), as an index of CO production, in post renal transplant recipients and their correlation to the graft haemodynamics, function and survival. This study was conducted on 40 subjects; they were classified into • two groups: - Group I: 20 patients post renal transplantation. Group II: 20 healthy subjects of matched age and sex as control group for the biochemical tests.