Some Studies on Rinderpest and PPR Vaccines in Sheep

Abstract

In this study, two groups each of 11 heads of susceptible sheep were vaccinated, the first group with an attenuated rinderpest (RP) vaccine, and the second, with a specific homologous peste des petits ruminants (PPR) vaccine, using a dose of 10' TCIDg of either vaccines inoculated subcutaneously. A third group of 5 susceptible sheep was held as a non-vaccinated contact control group for both groups. A comparative study between the results of vaccination of both groups regarding the antibody titres and their existence in serum of vaccinated sheep using serum neutralization test (SNT) and enzyme linked immunosorbent assay (ELISA) and also titres of interferon and its existence in serum of vaccinated sheep revealed that: I. By using RP virus antigen in SNT, the geometric mean RP antibody titres were: 5.8 and 1H.7, 3 and 4 weeks, respectively with significant increase in the titre after 4 weeks post RP vaccination. Geometric mean antibody titre of 13.2 was found 6 and up till 44 weeks post RP vaccination. Then geometric mean antibody titres of 12.4 was found 48 weeks post RP vaccination, it gradually decreased till being 2.3, 80 weeks post vaccination with a significant decrease in the titres after 60 weeks post vaccination. 2. By using RP virus antigen in ELISA, the geometric mean antibody titres were 7.79, 3 weeks post RP vaccination,