Microbiological Studies on Klebsiella Species in Chicken, Cow and Human

Abstract

Klebsiella pneumoniae is considered as a saprophyte in humans and other mammals, colonizing the gastrointestinal tract, skin, and nasopharynx as well as being a member of the Klebsiella genus of Enterobacteriaceae. K. pneumoniae is found in the environment and as a harmless commensally but is also a frequent nosocomial pathogen (causing urinary, respiratory and blood infections). The emergence of K. pneumoniae as a nosocomial pathogen in the US and Europe may be due in part to the acquisition of antibiotic resistance markers providing a selective advantage in hospital settings Klebsiella pneumoniae is an important hospital-acquired pathogen that causes severe morbidity and mortality among the newborn, the elderly, and immunocompromised patients. K. pneumoniae infections acquired in hospitals can be difficult to treat, as many strains are highly resistant to treatment with broad-spectrum Cephalosporins and Aminoglycosides. So, this study aimed to fulfill these items: A. Phenotypic and genotypic characterization of antibiotic resistance features of Klebsiella species from clinical human samples and different animal origin B. Studies on nosocomial K. pneumoniae in hospitals, especially ESBL-producing strains. C. Antibiotic resistant genes screening from animal and human isolates and monitoring the possible genetic correlation between isolates from different sources.