Comparative Study on the Effect of Mesenchymal Stem Cells Derived Exosomes Versus Platelets Rich Plasma on Healing of Skin Burn in Albino Rat. A Histological Study

Abstract

Burns are a common injury seen in emergency departments around the world and have significant morbidity and mortality. The clinical treatment of skin loss due to severe and massive burns or wounds continues to be a major problem in surgical procedures. Therefore, new strategies are needed to promote and help in wound healing and repair. Exosomes are a kind of membrane lipid vesicles of a diameter of 30-100 nm which represent an essential medium for intercellular communication. Recent studies have demonstrated that exosomes help tissue repair because of high stability, non-immune rejection and easy control of dosage and concentration. Platelet-rich plasma (PRP) is an autologous concentration of platelets in concentrated plasma. It has been used to promote soft and hard tissue healing and to significantly reduce wound healing time via providing tissues with concentrated platelet‐derived factors. Accordingly, the current study was carried out to compare the effect of MSCs derived exosomes versus PRP on the promotion of healing of experimentally induced second degree partial thickness burn injury in adult male albino rats. The thirty-two adult male albino rats were divided randomly into 4 groups. Group I (control). Group II (burn injury group) that will be left for spontaneous healing. Group III (burn injury treated with intradermal PRP injection). Group IV (burn injury treated with intradermal