Serum Procalcitonin, CRP, Lactate and Albumin as Predictors of Mortality in Critically Ill Cirrhotic Patients

Abstract

Cirrhotic patients may be asymptomatic or have symptoms such as ascites, encephalopathy, variceal hemorrhage, and jaundice, which are all signs of liver malfunction or portal hypertension. Other problems, such as infection, hepatocellular carcinoma, or kidney failure, may have an influence on these individuals' survival. Patients' survival rates are significantly reduced as a result of these problems. CRP and PCT levels have been studied as methods for detecting systemic inflammatory response syndrome "SIRS", which has been proven to predict the probability of mortality in cirrhotic individuals. CRP and PCT tests may be more exact to infection in cirrhotic individuals and can be utilized to detect bacterial infection early, particularly in the case of negative cultures. In severely sick hospitalized individuals, increased blood lactate levels have been characterized as a sign of poor organ perfusion. Most typically, increased lactate level in the setting of circulatory dysfunction is attributed to anaerobic glycolysis, and animal and human investigations have shown the link between organs hypoxia and lactate production.