Investigation of Genetic Drivers of Early Carcinogenesis in Hepatocellular Carcinoma

Abstract

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer accounts for ~90% of cases. It is the sixth most-common form of cancer worldwide and the third most common cause of cancer-related deaths worldwide. Incidence rates of HCC among men are 2 to 4 fold higher than rates among women. In Egypt; HCC is the most common cause of mortality- and morbidity-related cancer, and it ranks as the 4th common cancer. It is the most prevalent malignancy in men, the second most prevalent in women There are many risk factors in HCC development, including environmental factors, host- related risk factors and genetic- related factors. In Egypt, HCV is the most critical risk factor in liver cancer including HCC. Most HCC patients are often diagnosed at the advanced phase with poor prognosis, so we are in a critical need for characterization of molecular mechanistic target in HCC and tumor specific signaling pathways. These molecular targets are still major goal of HCC research, to can diagnosis and treat it at the early stage.