Association of Non-Alcoholic Fatty Liver Disease with Chronic Obstructive Lung Disease Patients: An Egyptian Study

Abstract

Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic triglyceride accumulation, known as steatosis, and the absence of significant alcohol consumption or secondary causes (eg, viral hepatitis). Stemming from over-nutrition and less physical activity, NAFLD has become the most common form of chronic liver damage. Additionally, prospective studies have documented that pulmonary function impairment is an independent predictor of cardiovascular disease-related morbidity and mortality. Chronic obstructive pulmonary disease (COPD) is a growing public health concern, causing considerable health-related costs and increased premature mortality. Although diagnosis is mainly based on chronic airflow limitation, as assessed by post-bronchodilator spirometry, COPD is nowadays considered a complex, heterogeneous and multi-organ condition. It is increasingly recognized that the presence of comorbidities such as obesity and/or cardiovascular (CV) and metabolic diseases substantially contributes to the recurrence of hospitalization for exacerbation and significantly impacts prognosis and the incidence of late CV events. The aim of the study was to determine the possible association between Chronic Obstructive Lung Disease and Non-Alcoholic Fatty Liver Disease. This was a cross sectional study, which was carried out at Outpatient Clinics at Ain Shams Hospital, 60 Egyptian Patients divided into two groups: Group 1:40 Patients diagnosed with COPD (Patients diagnosed by history of disease, smoking history and A ration of post bronchodilator