Post-operative outcome among donors of liver transplantation, retrospective study

Abstract

Background Living donor liver transplant (LDLT) is an accepted and widely practiced modality for treatment of end-stage liver disease. Donor safety has always been of paramount importance.

Aim To evaluate donor complications in LDLT.

Patients and methods This retrospective study was conducted at Ain Shams Specialized University Hospital (ASUSH) and Wadi El Nile Hospital on 1000 donors (all donors underwent LDLT from January 2001 till March 2020). They underwent clinical assessment and radiological and pathological investigations.

Results Only 36 (3.6%) cases of 997 donors had advanced Clavien gradient scores (grade III, grade IV, and grade V) with only two deaths, one following sepsis after bile leakage and the other due to massive pulmonary embolism in LDLT, from January 2001 to March 2020 at Ain Shams University Hospital and Wadi El Nile Hospital.

Conclusion LDLT is an accepted and widely practiced modality for treatment of end-stage liver disease. Donor safety has always been of paramount importance. Our center had very good outcomes following donor hepatectomies, and most donors returned to their predonation work within a reasonable period. Their willingness to donate again also further reinforced our results. Meticulous workup and strict adherence to protocols were the major reason we attribute to this. The Clavien grading system is useful to evaluate and compare surgical outcomes among various surgeons and centers.